Dynamic software updating c
We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4–21 years using quantitative four-dimensional maps and time-lapse sequences.
Thirteen healthy children for whom anatomic brain MRI scans were obtained every 2 years, for 8–10 years, were studied.
Imaging parameters were: echo time, 5 ms; repetition time, 24 ms; flip angle, 45°; acquisition matrix, 256 × 192; number of excitations, 1; and field of view, 24 cm.
With each major software/hardware upgrade, the reliability of the data before and after the upgrade was tested by scanning a set of subjects before and after the upgrade (20).
T1-weighted images with contiguous 1.5-mm slices in the axial plane and 2.0-mm slices in the coronal plane were obtained by using 3D spoiled-gradient recalled echo in the steady state.
Follow-up scans were then aligned to the baseline scan from the same subject, and mutually registered scans for each subject were linearly mapped into the International Consortium for Brain Mapping (ICBM) space (22).